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Article

Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients.

Scientific reports - 1 Nov 2021

López-Cotarelo Pilar, González-Jiménez Adela, Agudo-Jiménez Teresa, Abarca-Zabalía Judith, Aladro Yolanda, Pilo Belén, Comabella Manuel, Espino-Paisán Laura, Urcelay Elena

Abstract excerpt

One of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as eQTL in healthy controls. NDFIP1 shows interesting immune functions and is involved in the development of the central nervous system. We aimed at studying the NDFIP1 variant on activation and metabolism of immune cells. NDFIP1 mRNA and protein expression were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34725369
DOI: 10.1038/s41598-021-00528-8
PMCID: PMC8560952

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