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Article

LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation.

The Journal of clinical endocrinology and metabolism - 1 Aug 2010

Wegner L, Anthonsen S, Bork-Jensen J, Dalgaard L, Hansen T, Pedersen O, Poulsen P, Vaag A

Abstract excerpt

CONTEXT: Lamins are essential for nuclear shape and function. Polymorphisms in LMNA may associate with fat and muscle development and aging. OBJECTIVE: Our aim was to determine the influence of LMNA rs4641 on lean body mass (LBM) and fat mass (FM), in vivo metabolism, and expression of LMNA trans...

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Source

Identifiers

PMID: 20501691
DOI: 10.1210/jc.2009-2675

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20501691-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation.PMID 20501691Read ↗

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.Semantic proximity Read ↗

Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.Semantic proximity Read ↗

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.Semantic proximity Read ↗

Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives.Semantic proximity Read ↗

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.Semantic proximity Read ↗

New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome.Semantic proximity Read ↗

A recurrent familial partial lipodystrophy due to a monoallelic or biallelic LMNA founder variant highlights the multifaceted cardiac manifestations of metabolic laminopathies.Semantic proximity Read ↗

[Laminopathies: one gene, several diseases].Semantic proximity Read ↗

Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians.Semantic proximity Read ↗

<i>LMNA</i>R644C associates with hepatic steatosis in a large cohort and increases cellular lipid droplet accumulation<i>in vitro</i>Semantic proximity Read ↗

Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes.Semantic proximity Read ↗

Variation in the lamin A/C gene: associations with metabolic syndrome.Semantic proximity Read ↗

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