Article

Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients

2024-05-20

Abstract excerpt

Mutations of nuclear lamina-associated proteins LMNA and ZMPSTE24 have been associated with fatty liver. We report that the changes at the nuclear envelope we described in MASLD patients are caused by downregulation of ZMPSTE24, an enzyme that processes prelamin to mature lamin A. In addition, Zmpste24 mutant mice develop hepatic steatosis and exhibit upregulation of p53 target genes. p53 activity is also induced...

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Literature Corpus work: 1dce1af9-d3fc-5ef7-9ccc-e006b32d8f34
DOI: 10.1101/2024.05.16.594546

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