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Article

Variation in the lamin A/C gene: associations with metabolic syndrome.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2004

Steinle Nanette I, Kazlauskaite Rasa, Imumorin Ikhide G, Hsueh Wen-Chi, Pollin Toni I, O'Connell Jeffrey R, Mitchell Braxton D, Shuldiner Alan R

Abstract excerpt

OBJECTIVE: Metabolic syndrome is associated with increased risk for cardiovascular disease and type 2 diabetes mellitus (T2DM). The lamin A/C (LMNA) gene, mutations of which cause rare syndromes of severe insulin resistance and dyslipidemia, is located on chromosome 1q21-q24, a region linked to T2DM in several genome wide scans, including in the Old Order Amish. To determine whether polymorphisms in LMNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15205219
DOI: 10.1161/01.ATV.0000136384.53705.c9

Genes

LMNA
IGH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the lamin A/C gene: associations with metabolic syndrome.PMID 15205219Read ↗

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.Semantic proximity Read ↗

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.Semantic proximity Read ↗

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.Semantic proximity Read ↗

New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome.Semantic proximity Read ↗

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.Semantic proximity Read ↗

Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.Semantic proximity Read ↗

Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes.Semantic proximity Read ↗

LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation.Semantic proximity Read ↗

Metabolomics Ex/GWAS in the Amish reveals novel insights into cardiometabolic disease pathwaysSemantic proximity Read ↗

Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations.Semantic proximity Read ↗

<i>LMNA</i>R644C associates with hepatic steatosis in a large cohort and increases cellular lipid droplet accumulation<i>in vitro</i>Semantic proximity Read ↗

Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.Semantic proximity Read ↗

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