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Article

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.

Diabetes - 1 Mar 2007

Mesa José L, Loos Ruth J F, Franks Paul W, Ong Ken K, Luan Jian'an, O'Rahilly Stephen, Wareham Nicholas J, Barroso Inês

Abstract excerpt

Mutations in the LMNA gene, encoding the nuclear envelope protein lamin A/C, are responsible for a number of distinct disease entities including Dunnigan-type familial partial lipodystrophy. Dunningan-type lipodystrophy is characterized by loss of subcutaneous adipose tissue, insulin resistance,...

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Source

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Identifiers

PMID: 17327461
DOI: 10.2337/db06-1055
PMCID: PMC2668858

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17327461-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.PMID 17327461Read ↗

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.Semantic proximity Read ↗

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.Semantic proximity Read ↗

Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids.Semantic proximity Read ↗

Variation in the lamin A/C gene: associations with metabolic syndrome.Semantic proximity Read ↗

Heterogeneity of nuclear lamin A mutations in Dunnigan-type familial partial lipodystrophy.Semantic proximity Read ↗

New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome.Semantic proximity Read ↗

LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation.Semantic proximity Read ↗

Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians.Semantic proximity Read ↗

Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy.Semantic proximity Read ↗

Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes.Semantic proximity Read ↗

The role of genetic variation in the lamin a/c gene in the etiology of polycystic ovary syndrome.Semantic proximity Read ↗

Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians.Semantic proximity Read ↗

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