Article
Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.
Diabetes - 1 Mar 2007
Wegner Lise, Andersen Gitte, Sparsø Thomas, Grarup Niels, Glümer Charlotte, Borch-Johnsen Knut, Jørgensen Torben, Hansen Torben, Pedersen Oluf
Abstract excerpt
Mutations in LMNA encoding lamin A and C proteins cause monogenic syndromes characterized by muscular dystrophy and familial partial lipodystrophy. Eight tag single nucleotide polymorphisms in the LMNA locus were genotyped in 7,495 Danish whites and related to metabolic and anthropometric traits. The minor T-allele of rs4641 was nominally associated with type 2 diabetes (odds ratio 1.14 [95% CI 1.03-1.26], P =...
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