Article
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
Diabetes - 1 Mar 2007
Owen Katharine R, Groves Christopher J, Hanson Robert L, Knowler William C, Shuldiner Alan R, Elbein Steven C, Mitchell Braxton D, Froguel Philippe, Ng Maggie C Y, Chan Juliana C, Jia Weiping, Deloukas Panos, Hitman Graham A, Walker Mark, Frayling Timothy M, Hattersley Andrew T, Zeggini Eleftheria, McCarthy Mark I
Abstract excerpt
Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particularly rs4641; H566H) and metabolic syndrome components. We examined the relationship between LMNA...
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