Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

doi:10.1038/ejhg.2009.4

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Article

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

European journal of human genetics : EJHG - 1 Aug 2009

Reiling Erwin, van Vliet-Ostaptchouk Jana V, van 't Riet Esther, van Haeften Timon W, Arp Pascal A, Hansen Torben, Kremer Dennis, Groenewoud Marlous J, van Hove Els C, Romijn Johannes A, Smit Jan W A, Nijpels Giel, Heine Robert J, Uitterlinden André G, Pedersen Oluf, Slagboom P Eline, Maassen Johannes A, Hofker Marten H, 't Hart Leen M, Dekker Jacqueline M

Abstract excerpt

Mitochondria play an important role in many processes, like glucose metabolism, fatty acid oxidation and ATP synthesis. In this study, we aimed to identify association of common polymorphisms in nuclear-encoded genes involved in mitochondrial protein synthesis and biogenesis with type II diabetes mellitus (T2DM) using a two-stage design. In the first stage, we analyzed 62 tagging single nucleotide polymorphisms...

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PMID: 19209188
DOI: 10.1038/ejhg.2009.4
PMCID: PMC2986549

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