Article

Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA

2024-09-08

Abstract excerpt

DNA deaminase toxins are involved in interbacterial antagonism and the generation of genetic diversity in surviving bacterial populations. These enzymes have also been adopted as genome engineering tools. The single-stranded (ss)DNA deaminase SsdA represents the bacterial deaminase toxin family-2 (BaDTF2) and it deaminates ssDNA cytosines with little sequence context dependence, which contrasts with the AID/APOBEC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba18475a-d25d-54ff-9bc3-b446363bef4d
DOI: 10.1101/2024.09.08.611884

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdADOI 10.1101/2024.09.08.611884Read

Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddASemantic proximity Read

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificitySemantic proximity Read

Crystal Structure of DNA Cytidine Deaminase ABOBEC3G Catalytic Deamination Domain Suggests a Binding Mode of Full-length Enzyme to Single-stranded DNASemantic proximity Read

Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI.Semantic proximity Read

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors.Semantic proximity Read

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.Semantic proximity Read

A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility.Semantic proximity Read

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotesSemantic proximity Read

Structure of a DNA glycosylase that unhooks interstrand cross-links.Semantic proximity Read

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational VariabilitiesSemantic proximity Read

Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures.Semantic proximity Read

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.Semantic proximity Read