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Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere.

Nucleic acids research - 13 Nov 2025

Trasviña-Arenas Carlos H, Hashemian Mohammad, Malek Melody, Merrill Steven, Fisher Andrew J, David Sheila S

Abstract excerpt

The [4Fe-4S] cluster is an important cofactor of the base excision repair (BER) adenine DNA glycosylase MutY to prevent mutations associated with 8-oxoguanine (OG). Several MutYs lacking the [4Fe-4S] cofactor have been identified. Phylogenetic analysis shows that clusterless MutYs are distributed in two clades suggesting cofactor loss has occurred in multiple independent evolutionary events. Herein, we determined...

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Actinobacteria
Coenzymes
Crystallization
DNA Glycosylases
Iron-Sulfur Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation, alpha-Helical

Protein Domains

X-Ray Diffraction

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PMID: 41273174
DOI: 10.1093/nar/gkaf1127
PMCID: PMC12631127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere.PMID 41273174Read ↗

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.Semantic proximity Read ↗

Structural Connectivity Between the Zinc Linchpin Motif, the [4Fe-4S] cluster, and the active site orchestrates DNA repair in MUTYHSemantic proximity Read ↗

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repairSemantic proximity Read ↗

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The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.Semantic proximity Read ↗

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Theoretical study of DNA damage recognition via electron transfer from the [4Fe-4S] complex of MutY.Semantic proximity Read ↗

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