Article
The substrate binding interface of alkylpurine DNA glycosylase AlkD.
DNA repair - 1 Jan 2014
Mullins Elwood A, Rubinson Emily H, Eichman Brandt F
Abstract excerpt
Tandem helical repeats have emerged as an important DNA binding architecture. DNA glycosylase AlkD, which excises N3- and N7-alkylated nucleobases, uses repeating helical motifs to bind duplex DNA and to selectively pause at non-Watson-Crick base pairs. Remodeling of the DNA backbone promotes nucleotide flipping of the lesion and the complementary base into the solvent and toward the protein surface,...
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