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Article

Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer's disease.

The European journal of neuroscience - 1 Nov 2009

Zhong Li, Dong-hai Qiu, Hong-ying Liu, Qing-feng Lei

Abstract excerpt

Alzheimer's disease (AD) is a common, degenerative form of dementia characterized by the accumulation of plaques containing amyloid beta-peptides (A beta). Nicastrin (NCSTN) is a type I trans-membrane glycoprotein and an essential component of gamma-secretase, a multiprotein complex required for the production of the mature form of A beta. Overexpression of wild-type NCSTN increases A beta production, indicating...

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Source

Identifiers

PMID: 19840113
DOI: 10.1111/j.1460-9568.2009.06942.x

Genes

NCSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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