Article
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.
American journal of human genetics - 1 Jun 2002
Dermaut Bart, Theuns Jessie, Sleegers Kristel, Hasegawa Hiroshi, Van den Broeck Marleen, Vennekens Krist'l, Corsmit Ellen, St George-Hyslop Peter, Cruts Marc, van Duijn Cornelia M, Van Broeckhoven Christine
Abstract excerpt
Nicastrin regulates gamma-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer disease (EOAD) have been found. The gene encoding nicastrin (NCSTN) maps to 1q23, a region that has been linked and associated with late-onset Alzheimer disease (LOAD) in various genome screens. In 78 familial EOAD cases, we found 14...
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