Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.

Neuroscience letters - 22 Nov 2002

Orlacchio Antonio, Kawarai Toshitaka, Polidoro Mario, Stefani Alessandro, Orlacchio Aldo, St George-Hyslop Peter H, Bernardi Giorgio

Abstract excerpt

The biological study of the Nicastrin protein shows its crucial role in the pathogenesis of Alzheimer's disease (AD). We tested the hypothesis that the Nicastrin (NCSTN) gene might be genetically associated with AD. The association analysis of two single nucleotide polymorphisms (SNPs) in the coding region (cSNPs) of NCSTN were performed in an Italian population. No evidence of association was obtained between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Membrane Glycoproteins

Share to Polymerase Chain Reaction

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 12419494
DOI: 10.1016/s0304-3940(02)01022-4

Genes

NCSTN
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.PMID 12419494Read ↗

Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.Semantic proximity Read ↗

Nicastrin gene in familial and sporadic Alzheimer's disease.Semantic proximity Read ↗

Association between promoter polymorphisms of the nicastrin gene and sporadic Alzheimer's disease in North Chinese Han population.Semantic proximity Read ↗

Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.Semantic proximity Read ↗

No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease.Semantic proximity Read ↗

The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.Semantic proximity Read ↗

Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer's disease.Semantic proximity Read ↗

Genetic study of Sardinian patients with Alzheimer's disease.Semantic proximity Read ↗

Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.Semantic proximity Read ↗

A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.Semantic proximity Read ↗

Genetic study of neurexin and neuroligin genes in Alzheimer's disease.Semantic proximity Read ↗

Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.