Article
Nicastrin gene in familial and sporadic Alzheimer's disease.
Neuroscience letters - 15 Dec 2003
Confaloni Annamaria, Terreni Liana, Piscopo Paola, Crestini Alessio, Campeggi Lorenzo Malvezzi, Frigerio Carlo Sala, Blotta Ida, Perri Maria, Di Natale Manuela, Maletta Raffaele, Marcon Gabriella, Franceschi Massimo, Bruni Amalia C, Forloni Gianluigi, Cantafora Alfredo
Abstract excerpt
Nicastrin is a protein recently discovered associated to presenilins and involved in the production of amyloid beta peptide that accumulates in Alzheimer's disease (AD) brain. In this study the nicastrin gene was examined for unknown mutations and polymorphisms in 104 patients with familial AD (52 early-onset and 52 late-onset), 174 sporadic AD and 191 healthy neurological controls of Italian origin. The scanning...
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