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Article

Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.

Neuroscience letters - 3 Jun 2004

Orlacchio Antonio, Kawarai Toshitaka, Polidoro Mario, Paterson Andrew D, Rogaeva Ekaterina, Orlacchio Aldo, St George-Hyslop Peter H, Bernardi Giorgio

Abstract excerpt

The biological analysis of nicastrin (NCSTN) shows its crucial role in gamma-cleavage of the amyloid precursor protein. Inhibition of NCSTN demonstrated altered gamma-cleavage activity, suggesting its potential implication in Alzheimer's disease (AD). We sequenced the NCSTN gene promoter region and found two promoter single nucleotide polymorphisms (SNPs) at putative transcription binding sites, -796T/G and...

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Source

Identifiers

PMID: 15157994
DOI: 10.1016/j.neulet.2004.03.044

Genes

NCSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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