Article
No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease.
Neuroscience letters - 19 Dec 2003
Cousin Emmanuelle, Hannequin Didier, Macé Sandrine, Dubois Bruno, Ricard Sylvain, Génin Emmanuelle, Brun Christophe, Chansac Céline, Pradier Laurent, Frebourg Thierry, Brice Alexis, Campion Dominique, Deleuze Jean-François
Abstract excerpt
Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.
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