Article
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
Neurology - 13 Jul 2004
Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto A M, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C
Abstract excerpt
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD...
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