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Article

A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.

Life sciences - 18 Apr 2006

Mitsuda Noriaki, Yamagata Hidehisa D, Zhong Wangtao, Aoto Mamoru, Akatsu Hiroyasu, Uekawa Natsuko, Kamino Kouzin, Taguchi Keiko, Yamamoto Takayuki, Maruyama Mitsuo, Kosaka Kenji, Takeda Masatoshi, Kondo Ikuko, Miki Tetsuro

Abstract excerpt

Nicastrin interacts with gamma-secretase complex components predominantly via the N-terminal third of the transmembrane domain. The authentic transmembrane domain is critically required for the interaction with gamma-secretase complex components and for formation of an active gamma-secretase complex. In this study, we have identified a novel alternatively spliced transcript of nicastrin in human brain tissue....

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Source

Identifiers

PMID: 16303145
DOI: 10.1016/j.lfs.2005.10.007

Genes

NCSTN
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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