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Article

Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptide

19 Jan 2004

Abstract excerpt

The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. The subtypes also generate differential T cell repertoires as exemplified by distinct T cell responses...

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PMID: 14734527
DOI: 10.1084/jem.20031690

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