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Article

Comparative molecular dynamics analysis of tapasin-dependent and -independent MHC class I alleles.

Protein science : a publication of the Protein Society - 1 Feb 2007

Sieker Florian, Springer Sebastian, Zacharias Martin

Abstract excerpt

MHC class I molecules load antigenic peptides in the endoplasmic reticulum and present them at the cell surface. Efficiency of peptide loading depends on the class I allele and can involve interaction with tapasin and other proteins of the loading complex. Allele HLA-B*4402 (Asp at position 116) depends on tapasin for efficient peptide loading, whereas HLA-B*4405 (identical to B*4402 except for Tyr116) can...

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Identifiers

PMID: 17242432
DOI: 10.1110/ps.062568407
PMCID: PMC2203297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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