Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.

The Journal of experimental medicine - 7 Nov 2005

Tynan Fleur E, Elhassen Diah, Purcell Anthony W, Burrows Jacqueline M, Borg Natalie A, Miles John J, Williamson Nicholas A, Green Kate J, Tellam Judy, Kjer-Nielsen Lars, McCluskey James, Rossjohn Jamie, Burrows Scott R

Abstract excerpt

Thousands of potentially antigenic peptides are encoded by an infecting pathogen; however, only a small proportion induce measurable CD8(+) T cell responses. To investigate the factors that control peptide immunogenicity, we have examined the cytotoxic T lymphocyte (CTL) response to a previously undefined epitope ((77)APQPAPENAY(86)) from the BZLF1 protein of Epstein-Barr virus (EBV). This peptide binds well to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epstein-Barr Virus Infections

Share to Herpesvirus 4, Human

Share to HLA-B Antigens

Share to HLA-B35 Antigen

Share to Peptides

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 16275762
DOI: 10.1084/jem.20050864
PMCID: PMC2213230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.PMID 16275762Read ↗

The polymorphism at residue 156 determines the HLA-B*35 restricted peptide repertoire during HCMV infection.Semantic proximity Read ↗

Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.Semantic proximity Read ↗

Supermotif peptide binding and degeneracy of MHC: peptide recognition in an EBV peptide-specific CTL response with highly restricted TCR usage.Semantic proximity Read ↗

Potent T cell response to a class I‐binding 13‐mer viral epitope and the influence of HLA micropolymorphism in controlling epitope lengthSemantic proximity Read ↗

The Immunodominant Influenza A Virus M158–66Cytotoxic T Lymphocyte Epitope Exhibits Degenerate Class I Major Histocompatibility Complex Restriction in HumansSemantic proximity Read ↗

HLA peptide length preferences control CD8+ T cell responses.Semantic proximity Read ↗

Several HLA alleles share overlapping peptide specificities.Semantic proximity Read ↗

MHC allele-specific binding of a malaria peptide makes it become promiscuous on fitting a glycine residue into pocket 6.Semantic proximity Read ↗

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86.Semantic proximity Read ↗

Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).Semantic proximity Read ↗

Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes.Semantic proximity Read ↗

Distinct conformations of a peptide bound to HLA-DR1 or DRB5*0101 suggested by molecular modelling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.