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Article

Variant-specific contributions of CYP21A2 and CYP11B1 to the clinical and hormonal heterogeneity of polyendocrine metabolic ovarian syndrome phenotypes.

Molecular biology reports - 31 Jul 2026

Polat Seher, Simsek Yasin

Abstract excerpt

BACKGROUND: Polyendocrine Metabolic Ovarian Syndrome (PMOS) formerly known as Polycystic Ovary Syndrome (PCOS), characterized by hyperandrogenism, affects approximately 7.1-15.1% of women of reproductive age. While disease-causing CYP21A2 and CYP11B1 variants are well-studied, the contribution of synonymous variants to clinical and hormonal variations remains unclear. This study investigated whether synonymous...

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Source

Identifiers

PMID: 42536251
DOI: 10.1007/s11033-026-12498-z

Genes

CYP21A2
CYP11B1
SHBG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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