Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.

Fertility and sterility - 1 Apr 2011

Goodarzi Mark O, Louwers Yvonne V, Taylor Kent D, Jones Michelle R, Cui Jinrui, Kwon Soonil, Chen Yii-Der I, Guo Xiuqing, Stolk Lisette, Uitterlinden André G, Laven Joop S E, Azziz Ricardo

Abstract excerpt

OBJECTIVE: To evaluate association with polycystic ovary syndrome (PCOS) of 295 variants in 39 genes central to metabolic insulin signaling and glycogen synthase kinase 3β (GSK-3β) regulation, followed by replication efforts. DESIGN: Case-control association study, with discovery and replication cohorts. SETTING: Subjects were recruited from reproductive endocrinology clinics, and controls were recruited from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Models, Biological

Share to Polycystic Ovary Syndrome

Share to Receptor, Insulin

Share to Reproducibility of Results

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21300347
DOI: 10.1016/j.fertnstert.2011.01.015
PMCID: PMC3062664

Genes

INSR
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.PMID 21300347Read ↗

Genetic Markers of Polycystic Ovary Syndrome: Emphasis on Insulin ResistanceSemantic proximity Read ↗

Association of GWAS identified INSR variants (rs2059807 & rs1799817) with polycystic ovarian syndrome in Indian women.Semantic proximity Read ↗

Pathogenic variation in insulin resistance genes is common in polycystic ovary syndrome (PCOS): a strategy for causal gene discovery using whole-exome sequencing (WES) in complex traitsSemantic proximity Read ↗

Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review.Semantic proximity Read ↗

The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.Semantic proximity Read ↗

Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome.Semantic proximity Read ↗

Genetics of the polycystic ovary syndrome.Semantic proximity Read ↗

First evidence of genetic association between AKT2 and polycystic ovary syndrome.Semantic proximity Read ↗

Insulin resistance in women with polycystic ovary syndrome.Semantic proximity Read ↗

Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis.Semantic proximity Read ↗

Metabolic and hormonal profiling in polycystic ovarian syndrome: insights into INSR gene variations.Semantic proximity Read ↗

Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.