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Article

Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population.

Cancer detection and prevention - 1 Jan 2009

Ouerhani Slah, Rouissi Kamel, Marrakchi Raja, Ben Slama Mohamed R, Sfaxi Mohamed, Chebil Mohamed, ElGaaied Amel Benammar

Abstract excerpt

BACKGROUND: Cigarette smoking is the predominant risk factor for bladder cancer. This risk may be modified by polymorphisms in carcinogens metabolism genes; including those involving the N-acetyl transferase 2 (NAT2) which have been correlated with decreased enzyme activities. Moreover, folate insufficiency can induces carcinogenesis by decreasing DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) and...

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Source

Identifiers

PMID: 19588544
DOI: 10.1016/j.canep.2009.04.005

Genes

MTR
MTHFR
NAT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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