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Article

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts.

Genome biology - 1 Jan 2009

Levin Joshua Z, Berger Michael F, Adiconis Xian, Rogov Peter, Melnikov Alexandre, Fennell Timothy, Nusbaum Chad, Garraway Levi A, Gnirke Andreas

Abstract excerpt

Targeted RNA-Seq combines next-generation sequencing with capture of sequences from a relevant subset of a transcriptome. When testing by capturing sequences from a tumor cDNA library by hybridization to oligonucleotide probes specific for 467 cancer-related genes, this method showed high selectivity, improved mutation detection enabling discovery of novel chimeric transcripts, and provided RNA expression data....

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Identifiers

PMID: 19835606
DOI: 10.1186/gb-2009-10-10-r115
PMCID: PMC2784330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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