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Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

27 Feb 2021

Abstract excerpt

BACKGROUND: Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. METHODS: Five commercially available parallel sequencing assays were evaluated for their ability to detect gene fusions in eight cell lines and 18 FFPE tissue samples carrying a variety of known gene fusions. Four RNA-based assays and one DNA-based assay were...

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PMID: 33639937
DOI: 10.1186/s12920-021-00909-y

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