Article
Clinical utility of targeted RNA sequencing in cancer molecular diagnostics.
Nature medicine - 1 Oct 2025
Siddaway Robert, Glembocki Aida I, Arnoldo Anthony, Staunton Jordan, Liu Anthony P Y, Yuki Kyoko E, Yu Man, Cohen-Gogo Sarah, Shlien Adam, Villani Anita, Whitlock James A, Hitzler Johann, Tabori Uri, Levine Adrian B, Lafrenière Anthea, Nagy Anita, Chen Haiying, Ngan Bo-Yee, Somers Gino R, Abdelhaleem Mohamed, Chami Rose, Hawkins Cynthia
Abstract excerpt
Molecular diagnostics in oncology uses next-generation sequencing to improve diagnostic precision, prognostic prediction and therapeutic target selection. To date, most approaches have focused on DNA-based sequencing. However, RNA sequencing (RNA-seq) enables superior fusion detection and functional characterization of other alterations including splice site mutations and expression changes. Here we report our...
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