Article
PATHOLOGICAL SIGNIFICANCE OF CDH1/E-CADHERIN GERMLINE SEQUENCE VARIANTS IN BREAST CANCER PATIENTS.
Experimental oncology - 11 Oct 2023
Tabassum S, Munir F, Al Awadh A A, Anwar Z
Abstract excerpt
BACKGROUND: Germline alterations of the CDH1 (E-cadherin) tumor suppressor gene have been reported in several epithelial malignancies like hereditary diffuse gastric cancer and lobular breast cancer. E-cadherin plays a central role in proliferation, maintenance of cell-to-cell adhesion, polarity,...
Topics
- Animals
- Mice
- Humans
- Female
- Breast Neoplasms
- Genetic Predisposition to Disease
- Cadherins
- Cell Adhesion
- Stomach Neoplasms
- Germ Cells
- Pedigree
- Antigens, CD