Article
ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast.
Oncotarget - 6 Dec 2016
Ping Zheng, Siegal Gene P, Harada Shuko, Eltoum Isam-Eldin, Youssef Mariam, Shen Tiansheng, He Jianbo, Huang Yingjie, Chen Dongquan, Li Yiping, Bland Kirby I, Chang Helena R, Shen Dejun
Abstract excerpt
E-cadherin (CDH1) is a glycoprotein that mediates adhesion between epithelial cells and also suppresses cancer invasion. Mutation or deletion of the CDH1 gene has been reported in 30-60% cases of invasive lobular carcinoma (ILC). However, little is known about genomic differences between ILC with and without a CDH1 alteration. Therefore, we analyzed whole genome sequencing data of 169 ILC cases from The Cancer...
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