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Article

Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues

15 Oct 2009

Abstract excerpt

Genetic variability across the SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However whether genetic variability in the SNCA gene modulates the risk to develop sporadic PD via regulation of SNCA expression remained elusive. We studied the effect of PD...

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PMID: 19834617
DOI: 10.1371/journal.pone.0007480

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