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Article

Alpha-synuclein and familial Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 15 Jun 2009

Pankratz Nathan, Nichols William C, Elsaesser Veronika E, Pauciulo Michael W, Marek Diane K, Halter Cheryl A, Wojcieszek Joanne, Rudolph Alice, Pfeiffer Ronald F, Foroud Tatiana

Abstract excerpt

Whole gene duplications and triplications of alpha-synuclein (SNCA) can cause Parkinson's disease (PD), and variation in the promoter region (Rep1) and 3' region of SNCA has been reported to increase disease susceptibility. Within our cohort, one affected individual from each of 92 multiplex PD families showing the greatest evidence of linkage to the region around SNCA was screened for dosage alterations and...

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Source

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Identifiers

PMID: 19412953
DOI: 10.1002/mds.22524
PMCID: PMC3397145

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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