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Article

Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2008

Fuchs Julia, Tichopad Ales, Golub Yulia, Munz Marita, Schweitzer Katherine J, Wolf Björn, Berg Daniela, Mueller Jakob C, Gasser Thomas

Abstract excerpt

Genetic variability in the promoter and 3' region of the SNCA gene coding alpha-synuclein modulates the risk to develop sporadic Parkinson's disease (PD). Whether this is mediated by regulating alpha-synuclein expression levels remains unknown. Therefore, we analyzed levels of alpha-synuclein in blood and human post mortem brain tissue including the substantia nigra using quantitative real-time reverse...

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Source

Identifiers

PMID: 18162487
DOI: 10.1096/fj.07-9348com

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.PMID 18162487Read ↗

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