Article
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.
Human molecular genetics - 1 Sept 2009
Cronin Kenneth D, Ge Dongliang, Manninger Paul, Linnertz Colton, Rossoshek Anna, Orrison Bonnie M, Bernard David J, El-Agnaf Omar M A, Schlossmacher Michael G, Nussbaum Robert L, Chiba-Falek Ornit
Abstract excerpt
Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical question concerning the molecular pathogenesis of PD is what contributory role, if any, is played by the SNCA gene...
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