Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy.

Abstract excerpt

One of the two main hypotheses to account for ageing is antagonistic pleiotropy (AP). This model requires alleles that increase vital rates (reproduction or survival) at early age at the expense of vital rates at late age. An important focus of evolutionary studies has been to assess the relative abundance of AP-type aging alleles that arise through mutation. Here, we develop theory that predicts that senescence...

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