Article
Antagonistic Pleiotropy Framework for the Discovery of Molecular Mechanisms of Aging
2026-04-06
Abstract excerpt
The antagonistic pleiotropy (AP) mechanism of aging was first proposed by G.C. Williams in 1957. However, practical application of this theory for the targeted search of longevity interventions has lagged, owing to a lack of clear understanding of the conditions under which the same gene or trait may have opposite effects on fitness in young versus old organisms. We propose that changes in the somatic environment...
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Identifiers and source
- Literature Corpus work
- 8d521d96-15e9-5395-9bce-bc8cdedb0d84
- DOI
- 10.20944/preprints202604.0355.v1