Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What Is Antagonistic Pleiotropy?

Biochemistry. Biokhimiia - 1 Dec 2019

Mitteldorf J

Abstract excerpt

Antagonistic Pleiotropy (AP) is today the best-accepted theory for the evolutionary origin of aging. According to AP theory, aging is a side effect of genes that are selected for their contribution to fertility and other essential components of individual fitness. In this standard view, aging exists because the benefits of enhanced fertility early in life are linked logically or physically to the long-term...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Biological Evolution
Share to Genetics, Population

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Longevity

Share to Mutation

Share to Selection, Genetic

Source

Identifiers

PMID: 31870250
DOI: 10.1134/S0006297919120058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What Is Antagonistic Pleiotropy?PMID 31870250Read ↗

Is antagonistic pleiotropy ubiquitous in aging biology?Semantic proximity Read ↗

Why organisms age: Evolution of senescence under positive pleiotropy?Semantic proximity Read ↗

Antagonistic Pleiotropy Framework for the Discovery of Molecular Mechanisms of AgingSemantic proximity Read ↗

Antagonistic Pleiotropy in Human Disease.Semantic proximity Read ↗

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles.Semantic proximity Read ↗

Biological constraint, evolutionary spandrels and antagonistic pleiotropySemantic proximity Read ↗

Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy.Semantic proximity Read ↗

Evolutionary theories of aging and longevity.Semantic proximity Read ↗

Is cellular senescence an example of antagonistic pleiotropy?Semantic proximity Read ↗

Incorporating antagonistic pleiotropy into models for molecular replicators.Semantic proximity Read ↗

Evolution of senescence: late survival sacrificed for reproductionSemantic proximity Read ↗

Developmental Theory of Aging Revisited: Focus on Causal and Mechanistic Links Between Development and SenescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.