Article
Mutation and senescence: where genetics and demography meet.
Genetica - 1 Jan 1998
Promislow D E, Tatar M
Abstract excerpt
Two evolutionary genetic models-mutation accumulation and antagonistic pleiotropy-have been proposed to explain the origin and maintenance of senescence. In this paper, we focus our attention on the mutation accumulation model. We re-examine previous evidence for mutation accumulation in light of new information from large-scale demographic experiments. After discussing evidence for the predictions that have been...
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