Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary mechanisms of senescence.

Genetica - 1 Jan 1993

Charlesworth B

Abstract excerpt

This paper reviews theories of the evolution of senescence. The population genetic basis for the decline with age in sensitivity of fitness to changes in survival and fecundity is discussed. It is shown that this creates a pressure of selection that disproportionately favors performance early in life. The extent of this bias is greater when there is a high level of extrinsic mortality; this accounts for much the...

Topics

Age Factors
Aging
Animals
Biological Evolution
Genes
Genetic Variation
Humans
Life Expectancy
Models, Genetic
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8125262
DOI: 10.1007/BF01435984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8125262-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary mechanisms of senescence.PMID 8125262Read ↗

The evolutionary ecology of senescenceSemantic proximity Read ↗

Evolution of senescence: late survival sacrificed for reproductionSemantic proximity Read ↗

Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.Semantic proximity Read ↗

Evolutionary genetic bases of longevity and senescence.Semantic proximity Read ↗

Why organisms age: Evolution of senescence under positive pleiotropy?Semantic proximity Read ↗

Antagonistic Pleiotropy Framework for the Discovery of Molecular Mechanisms of AgingSemantic proximity Read ↗

Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response.Semantic proximity Read ↗

Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy.Semantic proximity Read ↗

Mutation and the evolution of ageing: from biometrics to system genetics.Semantic proximity Read ↗

Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster.Semantic proximity Read ↗

Testing evolutionary models of senescence: traditional approaches and future directions.Semantic proximity Read ↗

The evolution of senescence from a comparative perspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.