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Article

A genetic analysis of senescence in Drosophila.

Nature - 6 Jan 1994

Hughes K A, Charlesworth B

Abstract excerpt

Two attractive theories for the evolution of senescence are based on the principle that the force of natural selection decreases with age. The theories differ in the type of age-specific gene action that they assume. Antagonistic pleiotropy postulates that pleiotropic genes with positive effects early in life and negative effects of comparable magnitude late in life are favoured by selection, whereas genes with...

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PMID: 8107775
DOI: 10.1038/367064a0

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