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Article

Antagonistic pleiotropy, mutation accumulation, and human genetic disease.

Genetica - 1 Jan 1993

Albin R L

Abstract excerpt

The antagonistic pleiotropy theory of senescence is the most convincing theoretical explanation of the existence of aging. As yet, no locus or allele has been identified in a wild population with the features predicted by the pleiotropic theory. Human genetic diseases offer the opportunity to identify potentially pleiotropic alleles/loci. Four human genetic diseases--Huntington's disease, idiopathic...

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PMID: 8125276
DOI: 10.1007/BF01436004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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