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Article

Antagonistic pleiotropy, mutation accumulation, and human genetic disease.

Genetica - 1 Jan 1993

Albin R L

Abstract excerpt

The antagonistic pleiotropy theory of senescence is the most convincing theoretical explanation of the existence of aging. As yet, no locus or allele has been identified in a wild population with the features predicted by the pleiotropic theory. Human genetic diseases offer the opportunity to identify potentially pleiotropic alleles/loci. Four human genetic diseases--Huntington's disease, idiopathic...

Topics

Aging
Alleles
Alzheimer Disease
Female
Genes
Hemochromatosis
Humans
Huntington Disease
Male
Mutation
Myotonic Dystrophy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8125276
DOI: 10.1007/BF01436004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8125276-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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