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Article

Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response.

Evolution; international journal of organic evolution - 1 Feb 2018

Everman Elizabeth R, Morgan Theodore J

Abstract excerpt

As organisms age, the effectiveness of natural selection weakens, leading to age-related decline in fitness-related traits. The evolution of age-related changes associated with senescence is likely influenced by mutation accumulation (MA) and antagonistic pleiotropy (AP). MA predicts that age-related decline in fitness components is driven by age-specific sets of alleles, nonnegative genetic correlations within...

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Identifiers

PMID: 29214647
DOI: 10.1111/evo.13408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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