Article
On aging and age-specific effects of spontaneous mutations.
Evolution; international journal of organic evolution - 27 Jul 2023
Shenoi Vinesh N, Mital Avani, Brengdahl Martin I, Abson Katie, Henderson Gina, Maxwell Melody, Berger David, Friberg Urban
Abstract excerpt
Evolutionary theory assumes that mutations that cause aging either have beneficial early-life effects that gradually become deleterious with advancing age (antagonistic pleiotropy [AP]) or that they only have deleterious effects at old age (mutation accumulation [MA]). Mechanistically, aging is predicted to result from damage accumulating in the soma. While this scenario is compatible with AP, it is not...
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