Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of polymorphisms in porcine NOD2 on ligand recognition.

Molecular immunology - 1 Dec 2009

Jozaki Kosuke, Shinkai Hiroki, Tanaka-Matsuda Maiko, Morozumi Takeya, Matsumoto Toshimi, Toki Daisuke, Okumura Naohiko, Eguchi-Ogawa Tomoko, Kojima-Shibata Chihiro, Kadowaki Hiroshi, Suzuki Eisaku, Wada Yasuhiko, Uenishi Hirohide

Abstract excerpt

Nucleotide oligomerization domain 2 (NOD2) is a cytosolic pattern recognition receptor (PRR) that responds to muramyldipeptide (MDP), a component of peptidoglycans of gram positive and negative bacteria. NOD2 is involved in the modulation of signaling pathways for other PRRs, such as Toll-like receptors. Polymorphisms in NOD2 may evoke bowel disorders, and human Crohn's disease is significantly correlated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Europe
Share to Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Luciferases

Share to NF-kappa B

Share to Nod2 Signaling Adaptor Protein

Share to Sus scrofa

Source

Identifiers

PMID: 19822368
DOI: 10.1016/j.molimm.2009.09.030

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of polymorphisms in porcine NOD2 on ligand recognition.PMID 19822368Read ↗

NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population.Semantic proximity Read ↗

Porcine NOD1 polymorphisms with impaired ligand recognition and their distribution in pig populations.Semantic proximity Read ↗

Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.Semantic proximity Read ↗

Inborn errors E778K and G908R in NOD2 gene increase risk of nontuberculous mycobacterial infection: a computational studySemantic proximity Read ↗

Epistatic interaction between TLR4 and NOD2 in patients with Crohn's Disease: relation with risk and phenotype in a Spanish cohort.Semantic proximity Read ↗

Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.Semantic proximity Read ↗

Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.Semantic proximity Read ↗

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.Semantic proximity Read ↗

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.Semantic proximity Read ↗

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.Semantic proximity Read ↗

Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance.Semantic proximity Read ↗

Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.