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Article

Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance.

Developmental and comparative immunology - 1 Mar 2009

Uenishi Hirohide, Shinkai Hiroki

Abstract excerpt

Toll-like receptors (TLRs) are the most famous pattern-recognition receptors (PRRs); they monitor pathogen-associated molecular patterns and play a critical role in activation of the immune system against infection. TLR gene mutations may affect the gene products in terms of their ligand-binding ability or their signal transduction ability after ligand binding; such changes have a great influence on pathogen...

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PMID: 18590761
DOI: 10.1016/j.dci.2008.06.001

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