Article
rRNA modifications in an intersubunit bridge of the ribosome strongly affect both ribosome biogenesis and activity.
Molecular cell - 28 Dec 2007
Liang Xue-hai, Liu Qing, Fournier Maurille J
Abstract excerpt
The presence of nucleotide modifications in rRNA has been known for nearly 40 years; however, information about their roles is sparse. Here, we describe the consequences of depleting modifications from an intersubunit bridge (helix 69) of the ribosomal large subunit in yeast. Helix 69 interacts with both A and P site tRNAs and contains five modifications. Blocking one to two modifications has no apparent effect...
Topics
- Base Sequence
- Binding Sites
- Codon, Terminator
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Biosynthesis
- RNA, Fungal
- RNA, Ribosomal
- RNA, Ribosomal, 18S
- Ribosomes