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Article

Functional importance of individual rRNA 2'-O-ribose methylations revealed by high-resolution phenotyping.

RNA (New York, N.Y.) - 1 Apr 2008

Esguerra Jonathan, Warringer Jonas, Blomberg Anders

Abstract excerpt

Ribosomal RNAs contain numerous modifications at specific nucleotides. Despite their evolutionary conservation, the functional role of individual 2'-O-ribose methylations in rRNA is not known. A distinct family of small nucleolar RNAs, box C/D snoRNAs, guides the methylating complex to specific rRNA sites. Using a high-resolution phenotyping approach, we characterized 20 box C/D snoRNA gene deletions for altered...

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Identifiers

PMID: 18256246
DOI: 10.1261/rna.845808
PMCID: PMC2271359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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