Article
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Molecular cell - 9 Oct 2009
Lee Dung-Fang, Kuo Hsu-Ping, Liu Mo, Chou Chao-Kai, Xia Weiya, Du Yi, Shen Jia, Chen Chun-Te, Huo Longfei, Hsu Ming-Chuan, Li Chia-Wei, Ding Qingqing, Liao Tsai-Lien, Lai Chien-Chen, Lin Ann-Chi, Chang Ya-Hui, Tsai Shih-Feng, Li Long-Yuan, Hung Mien-Chie
Abstract excerpt
IkappaB kinase beta (IKKbeta) is involved in tumor development and progression through activation of the nuclear factor (NF)-kappaB pathway. However, the molecular mechanism that regulates IKKbeta degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)-based ubiquitin ligase, Kelch-like ECH-associated protein 1 (KEAP1), is responsible for IKKbeta ubiquitination. Depletion of KEAP1 led to the...
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