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Article

The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.

The EMBO journal - 19 May 2010

Lee Yu-Ru, Yuan Wei-Chien, Ho Hsuan-Chung, Chen Chun-Hau, Shih Hsiu-Ming, Chen Ruey-Hwa

Abstract excerpt

Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAPK activation remains largely unknown. Here, we identify the BTB-Kelch protein KLHL20 as a negative regulator of DAPK. KLHL20 binds DAPK and Cullin 3 (Cul3) via its Kelch-repeat domain and BTB domain, respectively. The KLHL20-Cul3-ROC1 E3 ligase complex promotes DAPK polyubiquitination,...

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Source

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Identifiers

PMID: 20389280
DOI: 10.1038/emboj.2010.62
PMCID: PMC2876967

Genes

KLHL20
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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