The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

doi:10.1016/j.celrep.2016.04.032

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Article

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Cell reports - 17 May 2016

Tortola Luigi, Nitsch Roberto, Bertrand Mathieu J M, Kogler Melanie, Redouane Younes, Kozieradzki Ivona, Uribesalgo Iris, Fennell Lilian M, Daugaard Mads, Klug Helene, Wirnsberger Gerald, Wimmer Reiner, Perlot Thomas, Sarao Renu, Rao Shuan, Hanada Toshikatsu, Takahashi Nozomi, Kernbauer Elisabeth, Demiröz Duygu, Lang Michaela, Superti-Furga Giulio, Decker Thomas, Pichler Andrea, Ikeda Fumiyo, Kroemer Guido, Vandenabeele Peter, Sorensen Poul H, Penninger Josef M

Abstract excerpt

The HECT domain E3 ligase HACE1 has been identified as a tumor suppressor in multiple cancers. Here, we report that HACE1 is a central gatekeeper of TNFR1-induced cell fate. Genetic inactivation of HACE1 inhibits TNF-stimulated NF-κB activation and TNFR1-NF-κB-dependent pathogen clearance in vivo. Moreover, TNF-induced apoptosis was impaired in hace1 mutant cells and knockout mice in vivo. Mechanistically, HACE1...

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PMID: 27160902
DOI: 10.1016/j.celrep.2016.04.032
PMCID: PMC4893156

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TNF
TRAF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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